Database error: Invalid SQL: select count(id) from pwn_comment where pid='31670' and iffb='1'
MySQL Error: 1194 (Table 'pwn_comment' is marked as crashed and should be repaired)
#0 dbbase_sql->halt(Invalid SQL: select count(id) from pwn_comment where pid='31670' and iffb='1') called at [D:\WWW\hzkjjypp\includes\db.inc.php:73] #1 dbbase_sql->query(select count(id) from {P}_comment where pid='31670' and iffb='1') called at [D:\WWW\hzkjjypp\comment\module\CommentContent.php:65] #2 CommentContent() called at [D:\WWW\hzkjjypp\includes\common.inc.php:526] #3 PrintPage() called at [D:\WWW\hzkjjypp\comment\html\index.php:13] Database error: Invalid SQL: select * from pwn_comment where pid='31670' and iffb='1' order by id limit 0,10
MySQL Error: 1194 (Table 'pwn_comment' is marked as crashed and should be repaired)
#0 dbbase_sql->halt(Invalid SQL: select * from pwn_comment where pid='31670' and iffb='1' order by id limit 0,10) called at [D:\WWW\hzkjjypp\includes\db.inc.php:73] #1 dbbase_sql->query(select * from {P}_comment where pid='31670' and iffb='1' order by id limit 0,10) called at [D:\WWW\hzkjjypp\comment\module\CommentContent.php:167] #2 CommentContent() called at [D:\WWW\hzkjjypp\includes\common.inc.php:526] #3 PrintPage() called at [D:\WWW\hzkjjypp\comment\html\index.php:13] 汉中康居家园小区【官方网站】
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发布于:2020-9-1 09:21:27  访问:973 次 回复: 篇
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F Gene Expression.Histone H1 ClassHistone H1, A Critical Protein Engaged
F gene expression.Histone H1 classHistone H1, a important protein engaged in the group and stabilization of chromatin structure [1, 23], consists of a number of variants (subtypes) current in a unique variety in many organisms. Ordinarily, the histone H1 set ranges from four to seven subtypes in animals and plants, achieving a highest of eleven proteins in mammalsKowalski Mobile Molecular Biology Letters (2016) 21:Website page 3 of[24]. The mammalian histone H1 subtypes are categorized according to its expression within the somatic (H1.1 1.5 and H1x) and germ (H1t, H1T2, H1oo) cells, of which subtypes H1.1 one.five and H1t are synthetized during the replication-dependent manner when synthesis in the subtype H1.0, H1x, H1T2 and H1oo is just not connected to the replication [1, 25]. The histone H1 variants enjoy a common role from the nucleosome orientation as well as in the creation of compacted, transcriptionally inert, larger get chromatin framework. Separately, H1 subtypes have an impact on neighborhood chromatin business and function, contributing to the gene activation or repression [24]. For that reason, the two redundancy and specificity is attributable for the histone H1 operating [25]. A redundant influence was demonstrated as a result of payment of removed H1.0 subtype because of the remaining set of H1 variants (H1c, H1d and H1e) from the H1.0-knock out mice strains [26]. The compensation also takes place within the doubly H1-deficient mice strains, concurrently deprived of the subtypes H1.0/H1.c, H1.0/H1.d and H1.0/H1e [27]. Whereas no phenotypic abnormality of mutated animals was observed, the payment comparable to the up-regulation of histone H1 variants is required to maintain the traditional stoichiometry amongst histone H1 and nucleosome. A discount of whole histone PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28609185 H1 content material resulting within the lower of nucleosome repeat size as well as in the formation of considerably less compacted, much more variable chromatin conformation have been noticed in triple-H1 (H1.c, H1.d and H1.e) null mice embryonic cells. Elimination of a few histone H1 variants bringing about the embryonic lethality indicate a limitation of histone H1 subtypes redundancy as well as a tendency to upkeep from the proper histone H1 information appropriate for typical development [28]. On the other hand, no compensatory Gardiquimod result was pointed out just after inducible depletion on the single H1 subtypes from the breast cancer cells. The noticed subtype-specific dependent changes inside the nucleosome spacing and chromatin business as well as from the repressed expression of mobile cycle genes and cell proliferation flaws recommend that histone H1 subtypes is likely to be functionally differentiated [29]. A lot of reports guidance the theory that histone H1 variants have distinct position in chromatin, triggering the person effects on some of cellular procedures (for modern review, see [30?2]). Specialization of histone PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26255881 H1 variants might be inferred from their unique properties relevant to the toughness of binding DNA and chromatin. In the same way, a distinction while in the degree of sequence conservation and distinct genomic spot may be joined to the assorted roles of histone H1 subtypes in chromatin areas or mobile varieties. FRAP experiments have proved which the mammalian histone H1 subtypes bind chromatin with various affinity with respect for their mobility, influenced from the lengths of C-terminal domain [33]. Histones H1.1 and H1.two acquiring the shortest Cterminal area, fast bind and dissociate involving chromatin web sites in distinction to histones H1.3, H1.4 and H1.five, that have an extended C-terminal domain and exc.
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